Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL
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چکیده
منابع مشابه
C . Increase HDL ( PPAR - alpha - mediated ) D . Reduce triglycerides ( PPAR - alpha - mediated ) Specific Drugs
There are three peroxisome proliferator-activated receptors (PPARs) subtypes which are commonly designated PPAR alpha, PPAR gamma and PPAR beta/delta. PPAR alpha activation increases high density lipoprotein (HDL) cholesterol synthesis, stimulates “reverse” cholesterol transport and reduces triglycerides. PPAR gamma activation results in insulin sensitization and antidiabetic action. Combined t...
متن کاملTriglycerides and HDL Cholesterol
D iabetes carries a high risk of atherosclerosis, and cardiovascular disease, especially coronary heart disease (CHD) and stroke, is by far the leading cause of death among patients with type 2 diabetes. Although statins reduce the risk of major vascular events by about one-fifth per millimole per liter reduction in LDL cholesterol, with similar proportional reductions in major coronary events,...
متن کاملPopulation-Based Resequencing of LIPG and ZNF202 Genes in Subjects with Extreme HDL Levels
Endothelial lipase (LIPG) and zinc finger protein 202 (ZNF202) are two pivotal genes in high density lipoprotein (HDL metabolism). We sought to determine their genetic contribution to variation in HDL-cholesterol levels by comprehensive resequencing of both genes in 235 individuals with high or low HDL-C levels. The selected subjects were 141 Whites (High HDL Group: n = 68, [Formula: see text] ...
متن کامل2nd International Symposium on Triglycerides and HDL
Lipoprotein subclasses Robert S. Rosenson (Chicago IL) discussed lipoprotein subclasses, inflammation, and cardiovascular disease (CVD) risk in the metabolic syndrome. Insulin resistance impairs VLDL particle clearance, leading to greater interchange of core triglyceride from VLDL with LDL and HDL, with LDL and HDL triglyceride enrichment leading both to become substrates for hepatic lipase, re...
متن کاملrs11613352 polymorphism (TT genotype) associates with a decrease of triglycerides and an increase of HDL in familial hypercholesterolemia patients.
INTRODUCTION AND OBJECTIVES Recent genome-wide association studies have identified a locus on chromosome 12q13.3 associated with plasma levels of triglyceride and high-density lipoprotein cholesterol, with rs11613352 being the lead single nucleotide polymorphism in this genome-wide association study locus. The aim of the study is to investigate the involvement of rs11613352 in a population with...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2007
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng1984